I am pretty new to Garuda, and I am using the Dragonized Gaming Release as of 10 days now -
SecondLife
Mixxx (not a game but I use it in SL)
League of Legends
World of Warcraft
Life is Fuedal
Cyberpunk 2077
All work using steam proton, the custom one from Garuda. SecondLife was the only one that required ANY tweaking outside of using proton. I do not blame Garuda for that, the client I use is not the game issued client, almost no one as old a SL person as I am does, and the client we DO use is set up for debian users and arch is not directly supported. It only took a day of looking around and sure enough a SL player had shared the needed libraries and now it runs better than it did in windows.