After watching 3 different videos on BlendOS again for someone like my roommate I can see the fixed file system and apps containerized individually bypassing any dependency issues altogether.
I find the declarative aspect of a NixOS system much more appealing than it being immutable (which is not without its drawbacks). From that point of view, a nix-flavored Garuda would be a sight to behold!
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So, don’t use VirtualBox. QEMU/KVM works much better, because it’s a Level 1 hypervisor - VMs run with near-bare-metal performance. I have Windows 11 installed in it, and running very well. I used this guide to perform the setup and installation. FWIW, I found it to be very complete, and informative, even though the process takes longer than VirtualBox. IMHO, the result’s well worth the one-time effort. I suggest you check the guide out,
Ernie
Pardon me being off-topic, but if you must use modern Office, I have to wonder why you would go through such effort instead of just using it in a browser, or even one of the Electron wrappers… 
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Offline and not connected to internet
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I have tried with kvm using GitHub - winapps-org/winapps: The winapps main project, forked from https://github.com/Fmstrat/winapps/ but the performance difference feels insignificant and the features I wanted click on desktop icon to directly launch windows apps from kde-menu were a hit or a miss. So I shifted then to Gnome Boxes which is simpler than both virt-manager and virtualbox.
The day ms-office and anti-cheat drivers would be supported by major linux distributions , Year of Linux will come , hopefully valve is getting the ball rolling for anti-cheat drivers in their version of linux kernel.
It’s still work in progress but I hope I get there to make it bootable immutable os
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